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3,3-Dimethyl-1-butanol (liquid)

Cat. No. M21629
3,3-Dimethyl-1-butanol (liquid) Structure
Synonym:

DMB; Neohexanol

Size Price Availability Quantity
1g USD 55  USD55 In stock
5g USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

3,3-Dimethyl-1-butanol (DMB) is an indirect inhibitors of TMAO, which can reduce plasma TMAO levels. 3,3-Dimethyl-1-butanol is a branched alkanol, which can be used as a ligand in the preparation of nickel based single-molecule magnets. 3,3-Dimethyl-1-butanol can be used as antifungal agents in the synthesis of lipophilic alkyl parabens.

Chemical Information
Molecular Weight 102.17
Formula C6H14O
CAS Number 624-95-3
Form Liquid
Solubility (25°C) Slightly soluble in water
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Abigail G Casso, et al. J Physiol. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice

[2] Chien-Ning Hsu, et al. Nutrients. Maternal 3,3-Dimethyl-1-Butanol Therapy Protects Adult Male Rat Offspring against Hypertension Programmed by Perinatal TCDD Exposure

[3] Chien-Ning Hsu, et al. Nutrients. Maternal 3,3-Dimethyl-1-Butanol Therapy Protects Adult Male Rat Offspring against Hypertension Programmed by Perinatal TCDD Exposure

[4] Jiawen Mao, et al. Neurosci Lett . Repeated 3,3-Dimethyl-1-butanol exposure alters social dominance in adult mice

[5] Jiawen Mao, et al. Neurosci Lett. Repeated 3,3-Dimethyl-1-butanol exposure alters social dominance in adult mice

[6] Kunpeng Wu, et al. Blood . The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

[7] Kunpeng Wu, et al. Blood. The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

[8] Guangji Wang, et al. J Nutr Biochem . 3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice

[9] Guangji Wang, et al. J Nutr Biochem. 3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice

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Keywords: 3,3-Dimethyl-1-butanol (liquid), DMB; Neohexanol supplier, inhibitors, activators

 
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