3,3-Dimethyl-1-butanol (DMB) is an indirect inhibitors of TMAO, which can reduce plasma TMAO levels. 3,3-Dimethyl-1-butanol is a branched alkanol, which can be used as a ligand in the preparation of nickel based single-molecule magnets. 3,3-Dimethyl-1-butanol can be used as antifungal agents in the synthesis of lipophilic alkyl parabens.
|Solubility (25°C)||Slightly soluble in water|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Lumasiran is a siRNA compound that reduces hepatic oxalate production by targeting ethanoic acid oxidase.
Givosiran is a small interfering RNA that targets hepatic aminofibrillar synthase 1 (ALAS1) messenger RNA, down-regulates ALAS1 mRNA, and prevents the accumulation of neurotoxic Î±-aminofibrillar acids and porphyrins, which can be used in porphyria-related studies.
Viltolarsen is a phosphorodiamidomorpholine antisense oligonucleotide that targets splicing of exon 53 of the myotonic dystrophy protein gene and can be used in the study of Duchenne muscular dystrophy (DMD).
Golodirsen is a phosphodiesteric morpholino oligomer (PMO) that specifically targets exon 53 of the pre-protein mRNA of myotonic dystrophy protein culture proteins, and can be used in studies related to Duchenne muscular dystrophy (DMD).
Eteplirsen is a synthetic antisense oligonucleotide that can be used in studies related to Duchenne muscular dystrophy (DMD).
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