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27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis.
Exp Cell Res. 2024 Mar 8;437(1):113979.
High level 27-HC impairs trophoblast cell invasion and migration via LXR in pre-eclampsia
27-Hydroxycholesterol purchased from AbMole
| Molecular Weight | 402.65 |
| Formula | C27H46O2 |
| CAS Number | 20380-11-4 |
| Solubility (25°C) | Ethanol 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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