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27-Hydroxycholesterol

Cat. No. M10348

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27-Hydroxycholesterol Structure
Synonym:

27-OHC

Size Price Availability Quantity
2mg USD 90  USD90 In stock
5mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis.

Product Citations
Chemical Information
Molecular Weight 402.65
Formula C27H46O2
CAS Number 20380-11-4
Solubility (25°C) Ethanol 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shaneabbas Raza, et al. Cancer Cell Int. The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells

[2] Siker Kimbung, et al. Endocr Relat Cancer. Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer

[3] Carolyn D DuSell, et al. Mol Endocrinol. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator

[4] X Fu, et al. J Biol Chem. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

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Keywords: 27-Hydroxycholesterol, 27-OHC supplier, Estrogen Receptor, inhibitors, activators

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