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L-Methionine methyl ester hydrochloride

Cat. No. M39301
L-Methionine methyl ester hydrochloride Structure
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Quality Control & Documentation
Biological Activity

L-Methionine methyl ester hydrochloride is a Methionine derivative.

Chemical Information
Molecular Weight 199.7
Formula C6H14ClNO2S
CAS Number 2491-18-1
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] John S Wang et al. Neuroreport. Homocysteine sensitizes the mouse neuromuscular junction to oxidative stress by nitric oxide

[2] Margit Kriechbaum et al. Inorg Chem. Peptide coupling between amino acids and the carboxylic acid of a functionalized chlorido-gold(I)-phosphane

[3] D Dalietos et al. Biol Trace Elem Res. Synthesis of enantiomeric pureCis-dichloroplatinum(II) amino acid complexes

[4] Sagiraju Sowmya et al. Vascul Pharmacol. Hydrogen sulfide: regulatory role on blood pressure in hyperhomocysteinemia

[5] O A al-Swayeh et al. J Pharm Pharmacol. Amino acids dilate resistance blood vessels of the perfused rat mesentery

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