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2-Naphthylacetic acid

Cat. No. M25495
2-Naphthylacetic acid Structure
Size Price Availability Quantity
1g USD 40  USD40 In stock
5g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

2-Naphthylacetic acid is a auxin which can promote plant growth.

Chemical Information
Molecular Weight 186.21
Formula C12H10O2
CAS Number 581-96-4
Solubility (25°C) DMSO 60 mg/mL
Methanol 60 mg/mL
acetone 50 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kaori Matsumoto, et al. Xenobiotica. Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro

[2] Kaori Matsumoto, et al. Xenobiotica. A metabolic pathway for the prodrυg nabumetone to the pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes

[3] Kenji Ogata, et al. Eur J Drug Metab Pharmacokinet. A novel injection strategy of flurbiprofen axetil by inhibiting protein binding with 6-methoxy-2-naphthylacetic acid

[4] Vijay Pawar, et al. AAPS PharmSciTech. Potential of Piperazinylalkylester Prodrυgs of 6-Methoxy-2-Naphthylacetic Acid (6-MNA) for Percutaneous Drυg Delivery

[5] T S Emudianughe, et al. Xenobiotica. Studies on the metabolism of arylacetic acids. 7. The influence of varying dose size upon the conjugation pattern of 2-naphthylacetic acid in the guinea pig, mouse and hamster

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