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2-ketoglutaric acid (alpha-ketoglutaric acid) is an intermediate produced by ATP or GTP in the Krebs cycle. 2-ketoglutaric acid also acts as the main carbon skeleton for nitrogen assimilation. 2-ketoglutaric acid is a reversible inhibitor of Tyrosinase (IC50=15 mM).
| Molecular Weight | 146.1 |
| Formula | C5H6O5 |
| CAS Number | 328-50-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Dunxin Shen, et al. Anal Biochem. Synthesis of α-Ketoglutaramic acid
[3] Zbigniew Zasłona, et al. Mol Cell. Cytokine-like Roles for Metabolites in Immunity
[4] Elisa Elena Baracco, et al. Aging (Albany NY). α-Ketoglutarate inhibits autophagy
| Related Tyrosinase Products |
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β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. |
| β-Tocopherol-d3
β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol. |
| Tyrosinase (206-214), human
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. |
| Ac-[Nle4, D-Phe7]-α-MSH (4-10)-NH2
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. |
| Tetrapeptide-30
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. |
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