Free shipping on all orders over $ 500

2-Aminoadenosine

Cat. No. M41559
2-Aminoadenosine Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

2-Aminoadenosine is an adenosine analog.

Chemical Information
Molecular Weight 282.26
Formula C10H14N6O4
CAS Number 2096-10-8
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Suresh S Pujari et al. J Org Chem. Oligonucleotides with "clickable" sugar residues: synthesis, duplex stability, and terminal versus central interstrand cross-linking of 2'-O-propargylated 2-aminoadenosine with a bifunctional azide

[2] Anilkumar R Kore et al. Nucleosides Nucleotides Nucleic Acids. An efficient process for synthesis of 2'-O-methyl and 3'-O-methyl guanosine from 2-aminoadenosine using diazomethane and the catalyst stannous chloride

[3] Frank Seela et al. J Org Chem. 7-Functionalized 7-deazapurine ribonucleosides related to 2-aminoadenosine, guanosine, and xanthosine: glycosylation of pyrrolo[2,3-d]pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

[4] K Grzeskowiak et al. J Mol Evol. Template-directed synthesis with 2-aminoadenosine

[5] G M Lamm et al. Nucleic Acids Res. Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts

Related Nucleoside Antimetabolite/Analog Products
8-Chloroguanosine 

8-Chloroguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
FMAU

FMAU is a thymidine analogue.
Xylocytidine

Xylocytidine is a cytidine analog.
N3-Allyluridine

N3-Allyluridine is a uridine analog.
Homouridine

Homouridine, is an uridine analogue.
  Catalog
Abmole Inhibitor Catalog




Keywords: 2-Aminoadenosine supplier, Nucleoside Antimetabolite/Analog, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.