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2-Amino-6-chloropurine

Cat. No. M31286
2-Amino-6-chloropurine Structure
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25g USD 20  USD20 In stock
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Biological Activity

2-Amino-6-chloropurine is a purine derivative used as a synthetic intermediate in organic synthesis and drug molecules (e.g. Famciclovir).

Chemical Information
Molecular Weight 169.57
Formula C5H4ClN5
CAS Number 10310-21-1
Form Solid
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] V Balachandran, et al. Spectrochim Acta A Mol Biomol Spectrosc. Tautomeric purine forms of 2-amino-6-chloropurine (N9H10 and N7H10): structures, vibrational assignments, NBO analysis, hyperpolarizability, HOMO-LUMO study using B3 based density functional calculations

[2] D K Kim, et al. J Med Chem. Synthesis and evaluation of 2-amino-9-(3-hydroxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir

[3] L L Bennett Jr, et al. Biochem Pharmacol. Mode of action of 2-amino-6-chloro-1-deazapurine

[4] J T Kusmierek, et al. Acta Chem Scand B. Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir

[5] M L Peterson, et al. J Med Chem. Synthesis and biological evaluation of carbocyclic analogues of lyxofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines

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