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2,7-Dideacetoxytaxinine J

Cat. No. M16383
2,7-Dideacetoxytaxinine J Structure
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2,7-Dideacetoxytaxinine J

Chemical Information
CAS Number 115810-14-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hong Li, et al. Phys Rev E. Tensor network simulation for the frustrated J_{1}-J_{2} Ising model on the square lattice

[2] Tuofan Li, et al. Virulence. The tyrosine phosphatase SHP-2 dephosphorylated by ALV-J via its Env efficiently promotes ALV-J replication

[3] Haowen Zhou, et al. J Chem Phys. Shape resonance determined from angular distribution in D 2 (v = 2, j = 2) + He → D 2 (v = 2, j = 0) + He cold scattering

[4] Keshav Datta, et al. Magn Reson Med. MRI of [2- 13 C]Lactate without J-coupling artifacts

[5] Nria Marc, et al. J Magn Reson. 2 J HH-resolved HSQC: Exclusive determination of geminal proton-proton coupling constants

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