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2,4-Dihydroxy-6-methoxyacetophenone

Cat. No. M17082
2,4-Dihydroxy-6-methoxyacetophenone Structure
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Biological Activity

2,4-Dihydroxy-6-methoxyacetophenone

Chemical Information
CAS Number 3602-54-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sahar Mofidi Tabatabaei, et al. Iran J Pharm Res. Phytochemical Study of Tanacetum Sonbolii Aerial Parts and the Antiprotozoal Activity of its Components

[2] Jun He, et al. Org Biomol Chem. Fischeriana A, a meroterpenoid with an unusual 6/6/5/5/5/6/6 heptacyclic carbon skeleton from the roots of Euphorbia fischeriana

[3] Elise Ivarsen, et al. J AOAC Int. Bioassay-Guided Chromatographic Isolation and Identification of Antibacterial Compounds from Artemisia annua L. That Inhibit Clostridium perfringens Growth

[4] Mohammad Sayed Alam, et al. Chem Pharm Bull (Tokyo). Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone

[5] Yong Rok Lee, et al. Molecules. An efficient and rapid synthetic route to biologically interesting pyranochalcone natural products

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