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2,4,5-Trimethoxybenzaldehyde

Cat. No. M18159
2,4,5-Trimethoxybenzaldehyde Structure
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Biological Activity

2,4,5-Trimethoxybenzaldehyde

Chemical Information
Molecular Weight 196.2
Formula C10H12O4
CAS Number 4460-86-0
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marcilio M de Moraes, et al. Front Plant Sci. Biosynthesis of Pellucidin A in Peperomia pellucida (L.) HBK

[2] Yu-Wen Wang, et al. J Agric Food Chem. 2,4,5-trimethoxybenzaldehyde, a bitter principle in plants, suppresses adipogenesis through the regulation of ERK1

[3] Alexandro Silva Nunes, et al. Exp Parasitol. Activity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognita

[4] Man-Ru Wu, et al. J Agric Food Chem. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes

[5] C-C Chen, et al. Lett Appl Microbiol. Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata

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