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17α-Estradiol

Cat. No. M10555
17α-Estradiol Structure
Synonym:

Epiestradiol

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

17 alpha-Estradiol is a 5α-reductase inhibitor, and it inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression. Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups.

Chemical Information
Molecular Weight 272.39
Formula C18H24O2
CAS Number 57-91-0
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Roberta S Santos, et al. Biol Sex Differ. The effects of 17 alpha-estradiol to inhibit inflammation in vitro

[2] Hong-Bing Zhang, et al. Jpn J Ophthalmol. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model

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Keywords: 17α-Estradiol, Epiestradiol supplier, Estrogen Receptor, inhibitors, activators


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