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N-ε-propargyloxycarbonyl-L-lysine hydrochloride

Cat. No. M25553
N-ε-propargyloxycarbonyl-L-lysine hydrochloride Structure

H-​L-​Lys(Poc)​-​OH hydrochloride

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Biological Activity

N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals.

Chemical Information
Molecular Weight 264.71
Formula C10H17ClN2O4
CAS Number 1428330-91-9
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Water 100 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Chuangchuang Xu, et al. Org Biomol Chem. Metal-free and regiospecific synthesis of 3-arylindoles

[2] Luyao Zheng, et al. Int J Pharm. Novel skin permeation enhancers based on amino acid ester ionic liquid: Design and permeation mechanism

[3] No authors listed. Carteolol

[4] P Suresh Jayasekara, et al. Synth Commun. Rapid synthesis of alkoxyamine hydrochloride derivatives from alkyl bromide and N,N'- di- tert-butoxycarbonylhydroxylamine ((Boc)2NOH)

[5] S Groszkowski, et al. Pol J Pharmacol Pharm. 1-Haloacylpiperazines

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Keywords: N-ε-propargyloxycarbonyl-L-lysine hydrochloride, H-​L-​Lys(Poc)​-​OH hydrochloride supplier, Fluorescent Dye, inhibitors, activators

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