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1-Naphthylamine hydrochloride

Cat. No. M40684
1-Naphthylamine hydrochloride Structure
Size Price Availability Quantity
1g USD 50  USD50 In stock
5g USD 75  USD75 In stock
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Biological Activity

1-Naphthylamine hydrochloride has a strong adsorption affinity for non-polar adsorbents and can be used for the determination of nitrate and nitrite.

Chemical Information
Molecular Weight 179.65
Formula C10H10ClN
CAS Number 552-46-5
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kristin L Szuhany et al. JAMA. Anxiety Disorders: A Review

[2] Taro Kishi et al. Mol Psychiatry. Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis

[3] Sarah E Hetrick et al. Cochrane Database Syst Rev. New generation antidepressants for depression in children and adolescents: a network meta-analysis

[4] Maggie Fedgchin et al. Int J Neuropsychopharmacol. Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

[5] Vanina Popova et al. Am J Psychiatry. Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study

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