P-glycoprotein P-glycoprotein

Cat.No.	Name	Information
M42232	ABCB1-IN-1	ABCB1-IN-1 is a potent ABCB1 inhibitor.
M42231	P-gp inhibitor 14	P-gp inhibitor 14 is a high affinity P-gp inhibitor.
M42230	FM04	FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM).
M42229	P-gp inhibitor 15	P-gp inhibitor 15 is a nonsubstrate inhibitor of P-glycoprotein (Pgp).
M42228	Neostenine	Neostenine is a stenine-type Stemona alkaloid, with antitussive activity.
M42227	OY-101	OY-101 is an orally active, potent and specific P-glycoprotein (P-gp) inhibitor.
M42226	Euphohelioscopin A	Euphohelioscopin A is a diterpenoid can be isolated from the Euphorbia helioscopia L.
M42225	Encequidar mesylate hydrochloride	Encequidar (HM30181) mesylate hydrochloride is a potent and selective inhibitor of P-glycoprotein (MDR1).
M39038	Evodine	Evodine, the major limonoid of Evodiae Fuctus, is a potent P-gp inhibitor. Evodine has protection against glutamateinduced toxicity by preserving the antioxidant defense system.
M39037	Phellamurin	Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity.
M39036	Epoxylathyrol	Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser.
M39035	Roquefortine C	Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria.
M29668	YS-370	YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity.
M29521	(R)-OY-101	(R)-OY-101 is an orally active and specific inhibitor of P-gp. (R)-OY-101 increases tumor sensitivity to anticancer agents. (R)-OY-101 has good activity in reversing tumor resistance and promoting apoptosis and can be used in cancer related research.
M29072	Laniquidar	Laniquidar (R101933) is a noncompetitive, third generation P-glycoprotein (P-gp) inhibitor with an IC50 of 0.51 μM. Laniquidar can be used for modulating multidrug resistance transporters. Laniquidar can also be used for studying acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Laniquidar has limited oral bioavailability.
M28889	XR9051 hydrochloride	XR9051 hydrochloride is an orally active and specific modulator of P-glycoprotein-mediated multidrug resistance (MDR).
M27670	MC70	MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1.
M21225	HTT-D3	HTT-D3 is a potent and orally active regulator of Huntington (HTT) splicing. HTT-D3 acts by promoting pseudo-exons containing the premature termination codon (psiExon), resulting in HTT mRNA degradation and reduced HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux and can be used in Huntington's disease research.
M19333	Roemerine	Roemerine, an aporphine alkaloid, isolated from the leaves of Fibraurea recisa Pierre, functions by interacting with P-glycoprotein. Roemerine reverses the multidrug-resistance phenotype with cultured cells.
M14251	Tariquidar methanesulfonate, hydrate	Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a K_d of 5.1 nM.

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P-glycoprotein P-glycoprotein

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