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NADPH Oxidase NADPH Oxidases (NOX)

Inhibitor

Cat.No.  Name Information
M4828 GKT137831 (Setanaxib) GKT137831 (Setanaxib) is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM.
M54722 Fluoflavine Fluoflavine is a selective NOX1 inhibitor with an IC50 value of 90 nM.Fluoflavine is >100 times more selective for NOX1 than NOX2, NOX3, NOX4, and has an IC50 >10 μM for all of them.Fluoflavine was shown to be a selective inhibitor of NOX1 with an IC50 of 360 nM in HEK293 cells.
M10049 GSK2795039 GSK2795039 is the first small molecule NADPH oxidase 2 (NOX2) inhibitor, with a mean pIC50 of 6 in different cell-free assays.
M9726 GLX351322 GLX351322 is an NADPH oxidase 4 inhibitor, which inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM.
M9608 APX-115 APX-115 is a potent, orally active inhibitor of pan NADPH oxidase (Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.
M8274 VAS2870 VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.
M6970 ML171 ML171 is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
M6452 Apocynin Apocynin is a nADPH-oxidase inhibitor.
M52559 NoxA1ds NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor.
M42528 GLX481369 GLX481369 is a redox active substance.
M42527 Noxa B BH3 Noxa B BH3 is a biological active peptide.
M42526 Noxa A BH3 Noxa A BH3 is a biological active peptide.
M42525 gp91 ds-tat gp91 ds-tat is a biological active peptide.
M42524 GLX481304 GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM.
M42523 Phox-I2 Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM.
M30971 GKT136901  GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity.
M30768 Mulberrofuran G  Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress. Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC50 of 3.99 μM.
M30760 VAS 3947  VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.
M28052 GKT136901 hydrochloride  GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.




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