| Cat.No. | Name | Information |
|---|---|---|
| M3517 | Lapatinib | Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
| M1802 | Lapatinib ditosylate monohydrate | Lapatinib (GW572016) ditosylate monohydrate is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM). |
| M1749 | Gefitinib | Gefitinib (ZD1839) is an EGFR tyrosine kinase and Akt phosphorylation inhibitor. Gefitinib significantly down-regulates CD47 expression and increases DC phagocytosis in non-small cell lung cancer cells such as PC9, H1437 and H1573. Gefitinib combined with CD47 antibody can enhance the phagocytosis of macrophages. |
| M5621 | Erlotinib (CP-358774) | Erlotinib (CP-358774) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. |
| M1913 | Neratinib | Neratinib (HKI-272) is an orally available, irreversible inhibitor of Her 2 tyrosine kinase. |
| M1850 | WZ4002 | WZ4002 is a novel, selective EGFR kinase inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) with IC50 of 8 nM. |
| M1869 | Dacomitinib | Dacomitinib (PF-00299804) is an oral, irreversible, small molecule inhibitor of human epidermal growth factor receptor-1, -2, and -4 tyrosine kinases. |
| M5307 | Afatinib dimaleate | Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. |
| M2424 | AZD9291 (Osimertinib) | Osimertinib (AZD-9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR, respectively. |
| M1677 | Afatinib | Afatinib (BIBW 2992) is a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor. |
| M42099 | EGFR-IN-85 | EGFR-IN-85 is an EGFR inhibitor. |
| M42098 | JGK-068S | JGK-068S is a potent EGFR inhibitor. |
| M42096 | EGFR mutant-IN-2 | EGFR mutant-IN-2 is an EGFR mutant inhibitor. |
| M42095 | EGFR-IN-88 | EGFR-IN-88 is an EGFR inhibitor (IC50: 87 nM). |
| M42094 | EGFR-IN-84 | EGFR-IN-84 is an EGFR inhibitor (IC50: 24 nM). |
| M42093 | EGFR-IN-87 | EGFR-IN-87 is a EGFR tyrosine kinase inhibitor. |
| M42092 | EGFR-IN-83 | EGFR-IN-83 is an EGFR inhibitor (IC50: 2.53 nM). |
| M42091 | EGFR/ErbB-2 inhibitor-1 | EGFR/ErbB-2 inhibitor-1 is a ErbB2/HER2 inhibitor. |
| M42090 | HER2-IN-13 | HER2-IN-13 is an HER2 inhibitor with an IC50 of 8 nM. |
| M42089 | HER2-IN-14 | HER2-IN-14 is an HER2 inhibitor with an IC50 of 18 nM. |
| M42088 | EGFR-IN-79 | EGFR-IN-79 is an EGFR inhibior with antitumor activity. |
| M42087 | BEBT-109 | BEBT-109 is a potent pan-mutant-selective EGFR inhibitor. |
| M42086 | PROTAC EGFR degrader 8 | PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. |
| M42085 | Erbstatin | Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect. |
| M42084 | Gefitinib N-oxide hydrochloride | Gefitinib N-oxide hydrochloride is the N-oxide derivative of Gefitinib. |
| M42083 | EGFR/BRAFV600E-IN-2 | E07 aptamer is an aptamer that targets human epidermal growth factor receptor (hEGFR). |
| M42082 | EGFR/BRAFV600E-IN-3 | EGFR/BRAFV600E-IN-3 is a EGFR, BRAFV600E and EGFRT790M inhibitor with IC50 value of 57 nM, 68 nM and 9.70 nM. |
| M42081 | SIQ17 | SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. |
| M42080 | GW583340 dihydrochloride | GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). |
| M42079 | OK2 | OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. |
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