CDK Cyclin-dependent kinase

Cat.No.	Name	Information
M1806	PD 0332991 HCL	PD-0332991 HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc.
M1974	Roscovitine (Seliciclib)	Roscovitine is a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
M2112	LY2835219 mesylate	LY2835219 mesylate is an orally available inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM, respectively.
M1807	SCH727965 (dinaciclib)	SCH727965 (Dinaciclib) is a potent and selective CDK inhibitor with IC50 values of 1, 1, 3 and 4 nM for CDK2, CDK5, CDK1 and CDK9, respectively.
M3519	PHA-848125	PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7.
M5228	THZ1	THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
M1710	Flavopiridol	Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively.
M6167	Palbociclib	Palbociclib is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
M5305	RO-3306	RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases.
M4889	Ribociclib succinate (LEE011 succinate)	Ribociclib succinate (LEE011 succinate) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
M55930	LY3177833 monhydrate	LY3177833 monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively.
M55929	Senexin A hydrochloride	Senexin A hydrochloride is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription.
M55308	ARTS-021	ARTS-021 is a potent, reversible, orally available cyclin-dependent kinase 2 (CDK 2) selective inhibitor that inhibits CDK2 at nanomolar potency and with over 600-fold selectivity against CDK1.
M55227	T025	T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively.
M54712	PF-07224826	PF-07224826 is a CDK2/4/6 inhibitor.
M54711	INCB123667	INCB123667 is a CDK2 inhibitor.
M54709	Q901	Q901 is a CDK7 inhibitor for tumor-related studies.
M54708	NUV-422	NUV-422 is a CDK2/4/6 inhibitor that can be used in studies related to malignant gliomas.
M54706	GTAEXS-617	GTAEXS-617 is a highly selective small molecule non-covalent CDK7 inhibitor.
M54705	BLU-222	BLU-222 is a best-in-class, oral, potent and selective CDK2 inhibitor.
M54704	AZD8421	AZD8421 is a selective CDK2 inhibitor (IC50=9 nM) with selectivity for CDK1, CDK4 and CDK6. AZD8421 can target CDK2 and can be used in tumor-related studies.
M54632	XPW1	XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity.
M53361	[pThr3]-CDK5 Substrate	[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.
M53360	Cdk2/Cyclin Inhibitory Peptide I	Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner.
M53359	PSTAIR	PSTAIR is a monoclonal antibody that recognizes the PSTAIR sequence in Cdc28, PSTAIR can be used as loading control.
M49519	NSC693868	NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively.
M49517	K00546	K00546 is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively.
M49516	Indirubin-5-sulfonate	Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively.
M49515	Indirubin-3'-monoxime-5-sulphonic acid	Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively.
M49514	GSK-3/CDK5/CDK2-IN-1	GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a.

By Signaling Pathways

By Product Type

Signaling Pathways

CDK Cyclin-dependent kinase

Get to Know Us

Customer Support

Resources

Contact Us