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BCRP/ABCG2/MXR/ABCP Breast cancer resistance protein


Cat.No.  Name Information
M49906 Zamicastat Zamicastat is a dopamine β-hydroxylase (DBH) inhibitor that crosses the blood-brain barrier and causes central and peripheral effects. In addition, Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 μM and 17.0 μM, respectively.
M9479 YHO-13177 YHO-13177 is a potent and specific inhibitor of breast cancer resistance protein (BCRP/ABCG2).
M7810 Fumitremorgin C Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds.
M6870 Ko 143 Ko 143 is a potent and selective BCRP inhibitor.
M5193 KS176 KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter with IC50 values of 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays, respectively.
M49911 CCTA-1523 CCTA-1523 is a potent, selective, reversible, and orally active ABCG2 inhibitor.CCTA-1523 exhibits cytotoxicity and anticancer activity.
M49910 Ac32Az19 Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC50 value of 13 nM in BCRP overexpressing HEK293/R2 cells.
M49909 ML230 ML230 is a selective inhibitor of the ATP-binding transporter subtype ABCG2, and its inhibitory effect on ABCG2 was 36 times that of ABCB1, with EC50 values of 0.13 μM and 4.65 μM, respectively.
M49908 (S)-ML753286 (S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor that inhibits BCRP efflux transporter protein with an IC50 of 0.6 μM.
M49907 Efflux inhibitor-1 Efflux inhibitor-1 is a pyrazolo[1,5-a]pyrimidine efflux inhibitor that also selectively targets ABCG2, with IC50s of 0.45 μM and 2.17 μM, respectively.
M42163 ABCG2-IN-2 ABCG2-IN-2 is a potent ABCG2 inhibitor with favorable oral pharmacokinetic profiles in mice.
M42162 ABCG2-IN-1 ABCG2-IN-1 is an orally active ABCG2 inhibitor with an IC50 of 0.13 μM.
M30873 YHO-13351 free base  YHO-13351 free base is the precursor of YHO-13177, which is a potent and specific inhibitor of BCRP.
M30477 6,8-Diprenylnaringenin 6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin.
M28213 YHO-13351  YHO-13351 is the precursor of YHO-13177, which is a potent and specific inhibitor of BCRP.
M14186 ML753286 ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM.
M8354 Symadex Symadex is an FMS-like tyrosine kinase 3 (FLT3) and topoisomerase-II inhibitor; ABCG2 substrate; cell cycle modulator.
M8062 CP-100356 monohydrochloride CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter.

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