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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M1658 | Axitinib | Axitinib (AG013736) inhibits multiple targets including VEGFR, PDGFR and cKit. |
| M2194 | SU5402 | SU5402 is a potent and selective VEGFR and FGFR inhibitor with IC50 values of 0.02, 0.03, 0.51 and > 100 μM for VEGFR2, FGFR1, PDGFRβ and EGFR respectively. |
| M1838 | Masitinib | Masitinib is a tyrosine kinase inhibitor targeting stem cell factor receptor (c-kit) and platelet-derived growth factor (PDGF) receptor. |
| M1956 | Apatinib mesylate | Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor of VEGFR2 with an IC50 of 2.43 nM. |
| M1841 | Lenvatinib | Lenvatinib (E7080) is a potent inhibitor of multiple tyrosine kinases, including VEGF-R3 tyrosine kinase (IC50=5.2 nM) and VEGF-R2 tyrosine kinase (IC50=4.0 nM). |
| M20877 | Toceranib phosphate | Toceranib phosphate is a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. |
| M20835 | Seralutinib (GB002) | Seralutinib (PK10571, GB002) is a novel PDGFR kinase inhibitor with IC50s of 8 nM and 10 nM for PDGFRα and PDGFRβ in enzyme assays, respectively. |
| M20740 | SU5204 | SU5204 is a tyrosine kinase inhibitor with IC50 of 4 μM and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively. |
| M20715 | CS-2660 (JNJ-38158471) | CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3. |
| M20700 | Vorolanib (X-82) | Vorolanib is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities. |
| M20586 | ZD-4190 | ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively. |
| M20360 | WAY-302159 | WAY-302159 is a novel VEGFR-2 inhibitor. |
| M20358 | WAY-340935 | WAY-340935 is a VEGFR2 kinase inhibitor. |
| M20248 | WAY-637081 | WAY-637081 is a VEGFR2 inhibitor |
| M20201 | WAY-607500 | WAY-607500 is a VEGFR inhibitor. |
| M20170 | WAY-357919 | WAY-357919 is a inhibitor of vascular endothelial growth factor receptor-2. |
| M20107 | WAY-325185 | WAY-325185 altering the lifespan of a eukaryotic organism |
| M20062 | WAY-297629 | WAY-297629 is a VEGFR2 inhibitor. |
| M20044 | WAY-271147 | WAY-271147 is a VEGFR inhibitor |
| M20043 | WAY-271146 | WAY-271146 is a VEGFR inhibitor |
| M20021 | GI-555736 | GI-555736 altering the lifespan of a eukaryotic organism |
| M20019 | CL-230482 | CL-230482 is a PDGFR inhibitor. |
| M20016 | AY-20590 | AY-20590 is a inhibitor of Mcl-1 (for the treatment of cancer and other diseases). |
| M14922 | TG 100801 | TG 100801 is a prodrug that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. |
| M14921 | Telatinib mesylate | Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively. |
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