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VEGFR/PDGFR Vascular Endothelial Growth Factor Receptor/platelet-derived growth factor receptor

Inhibitors

Cat.No.  Name Information
M1658 Axitinib Axitinib (AG013736) inhibits multiple targets including VEGFR, PDGFR and cKit.
M2194 SU5402 SU5402 is a potent and selective VEGFR and FGFR inhibitor with IC50 values of 0.02, 0.03, 0.51 and > 100 μM for VEGFR2, FGFR1, PDGFRβ and EGFR respectively.
M1838 Masitinib Masitinib is a tyrosine kinase inhibitor targeting stem cell factor receptor (c-kit) and platelet-derived growth factor (PDGF) receptor.
M1956 Apatinib mesylate Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor of VEGFR2 with an IC50 of 2.43 nM.
M1841 Lenvatinib Lenvatinib (E7080) is a potent inhibitor of multiple tyrosine kinases, including VEGF-R3 tyrosine kinase (IC50=5.2 nM) and VEGF-R2 tyrosine kinase (IC50=4.0 nM).
M20877 Toceranib phosphate Toceranib phosphate is a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively.
M20835 Seralutinib (GB002) Seralutinib (PK10571, GB002) is a novel PDGFR kinase inhibitor with IC50s of 8 nM and 10 nM for PDGFRα and PDGFRβ in enzyme assays, respectively.
M20740 SU5204 SU5204 is a tyrosine kinase inhibitor with IC50 of 4 μM and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively.
M20715 CS-2660 (JNJ-38158471) CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM,while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.
M20700 Vorolanib (X-82) Vorolanib is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities.
M20586 ZD-4190 ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively.
M20360 WAY-302159 WAY-302159 is a novel VEGFR-2 inhibitor.
M20358 WAY-340935 WAY-340935 is a VEGFR2 kinase inhibitor.
M20248 WAY-637081 WAY-637081 is a VEGFR2 inhibitor
M20201 WAY-607500 WAY-607500 is a VEGFR inhibitor.
M20170 WAY-357919 WAY-357919 is a inhibitor of vascular endothelial growth factor receptor-2.
M20107 WAY-325185 WAY-325185 altering the lifespan of a eukaryotic organism
M20062 WAY-297629 WAY-297629 is a VEGFR2 inhibitor.
M20044 WAY-271147 WAY-271147 is a VEGFR inhibitor
M20043 WAY-271146 WAY-271146 is a VEGFR inhibitor
M20021 GI-555736 GI-555736 altering the lifespan of a eukaryotic organism
M20019 CL-230482 CL-230482 is a PDGFR inhibitor.
M20016 AY-20590 AY-20590 is a inhibitor of Mcl-1 (for the treatment of cancer and other diseases).
M14922 TG 100801 TG 100801 is a prodrug that generates TG 100572 by de-esterification in development to treat age-related macular degeneration.
M14921 Telatinib mesylate Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively.



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