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Regorafenib Monohydrate

Cat. No. M5005
Regorafenib Monohydrate Structure
Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 200 In stock
100mg USD 300 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Regorafenib targets both tumor cell proliferation and tumor vasculature through inhibition of receptors of tyrosine kinases (VEGFR, KIT, RET, FGFR, and PDGFR) and serine/threonine kinases (Raf and p38MAPK).Regorafenib suppresses growth of human Hep3B, PLC/PRF/5 and HepG2 cells in a concentration- and time-dependent manner

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 500.83
Formula C21H17ClF4N4O4
CAS Number 1019206-88-2
Purity >99%
Solubility 10 mM in ethanol
Storage at -20°C
References

Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions.
Heng DY,et.al. Ther Adv Med Oncol. 2010 Jan;39-49. PMID: 21789125.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Regorafenib Monohydrate supplier, VEGFR/PDGFR, inhibitors

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