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Humanized vascular endothelial growth factor (VEGF) antibody (bevacizumab; Avastin) is a highly effective monoclonal antibody against metastatic colorectal cancer and several other advanced late stage cancers.
| Cell Experiment | |
|---|---|
| Cell lines | NSCLC cell lines |
| Preparation method | Six NSCLC cell lines were seeded (~2,000–5,000 cells per well, depending on cell type) onto 96-well plates. After 24 h of incubation, cells were treated with erlotinib (0–20 µmol/L), bevacizumab (0–20 ng/mL) or a combination of these agents (erlotinib 1 µmol/L; bevacizumab 10 ng/mL) for 72 h in serum-containing medium. The viability was determined by MTS assay (Promega, Madison, WI) according to the manufacturer’s instructions. |
| Concentrations | 0–20 ng/mL |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | Female Wistar rats |
| Formulation | 0.9%sodium chloride solution |
| Dosages | 30 mg/kg |
| Administration | i.p. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | |
| Formula | |
| CAS Number | 216974-75-3 |
| Purity | >98% |
| Solubility | 10 mM in DMSO |
| Storage | at -20°C |
Effect of Avastin on the migration and invasion of pterygium fibroblasts.
Liu W, et al. Eye Sci. 2014 Dec;29(4):214-8. PMID: 26016073.
Injectable biodegradable hydrogels from vitamin D-functionalized polycarbonates for the delivery of avastin with enhanced therapeutic efficiency against metastatic colorectal cancer.
Lee AL, et al. Biomacromolecules. 2015 Feb 9;16(2):465-75. PMID: 25543531.
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