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ROCK Rho-associated protein kinase

Inhibitors

Cat.No.  Name Information
M1817 Y-27632 dihydrochloride Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2.
M5168 GSK269962A GSK269962A is a potent ROCK inhibitor with IC50 values of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2, respectively.
M20999 Y-27632 Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
M20640 MBQ-167 MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.
M20607 BQU57 BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.
M20596 K-Ras(G12C) inhibitor 6 K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C).
M20595 K-Ras(G12C) inhibitor 12 K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
M20594 6H05 6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).
M20378 WAY-624704 WAY-624704 is a ROCK inhibitor.
M20340 WAY-301300 WAY-301300 is a Rho kinase inhibitor.
M20311 WAY-226683 WAY-226683 is a Rho kinase inhibitor.
M20286 WL-300778 WL-300778 is a inhibitor of Rho associated protein kinases (ROCK1 and 2)
M20280 WAY-658513 WAY-658513 is a inhibitor of ROCK, ERK, GSK, and AGC protein kinases.
M20278 WAY-657460 WAY-657460 is a ROCK inhibitor
M20277 WAY-656935 WAY-656935 is a ROCK Inhibitor
M20275 WAY-655978 WAY-655978 is a inhibitor of ROCK, ERK, GSK, and AGC protein kinases.
M20150 WAY-346940 WAY-346940 is a Rho-kinase inhibitor.
M20099 WAY-322940 WAY-322940 is a inhibitor of Rho kinase.
M13733 Y-33075 Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
M13732 SAR407899 hydrochloride SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
M13731 ROCK inhibitor-2 ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively.
M13730 RKI-1447 dihydrochloride RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis.



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