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Y-39983 dihydrochloride

Cat. No. M5123

Y-39983 dihydrochloride Structure

Synonym: Y-33075 dihydrochloride

Size Price Availability Quantity
2mg USD 120 In stock
5mg USD 180 In stock
10mg USD 320 In stock
50mg USD 1060 In stock
100mg USD 1600 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Y-39983 Hcl is a selective ROCK inhibitor derived from Y-27632, inhibited ROCK more potently than Y-27632.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 353.25
Formula C16H18Cl2N4O
CAS Number 173897-44-4
Purity >99%
Solubility 10 mM in DMSO
10 mM in H2O
Storage at -20°C
References


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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Y-39983 dihydrochloride, Y-33075 dihydrochloride supplier, ROCK, inhibitors

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