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Y-39983 dihydrochloride

Cat. No. M5123
Y-39983 dihydrochloride Structure
Synonym:

Y-33075 dihydrochloride

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 135  USD135 In stock
25mg USD 300  USD300 In stock
50mg USD 500  USD500 In stock
100mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

Y-39983 Hcl is a selective ROCK inhibitor derived from Y-27632, inhibited ROCK more potently than Y-27632.

Chemical Information
Molecular Weight 353.25
Formula C16H18Cl2N4O
CAS Number 173897-44-4
Solubility (25°C) 10 mM in DMSO
10 mM in Water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1]

[2]

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