Free shipping on all orders over $ 500

Y-39983 dihydrochloride

Cat. No. M5123
Y-39983 dihydrochloride Structure
Synonym:

Y-33075 dihydrochloride

Size Price Availability
2mg USD 100 Out of stock
5mg USD 135 Out of stock
10mg USD 220 Out of stock
50mg USD 880 Out of stock
100mg USD 1450 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Y-39983 Hcl is a selective ROCK inhibitor derived from Y-27632, inhibited ROCK more potently than Y-27632.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 353.25
Formula C16H18Cl2N4O
CAS Number 173897-44-4
Purity >98%
Solubility 10 mM in DMSO
10 mM in Water
Storage at -20°C
References


.


.

Related ROCK Products
BDP5290

BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

SLx-2119

SLx-2119, also known as KD-025, is an orally bioavailable inhibitor of ROCK-II with IC50 of 105 nM.

ZINC00881524

ZINC00881524 is a potent and selective ROCK inhibitor.

HA 1100 hydrochloride

HA 1100 hydrochloride is a cell-permeable, selective Rho-kinase inhibitor.

Ripasudil (K-115) dihydrate

Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Y-39983 dihydrochloride, Y-33075 dihydrochloride supplier, ROCK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.