Free shipping on all orders over $ 500

SLx-2119

Cat. No. M9209
SLx-2119 Structure
Synonym:

KD-025

Size Price Availability Quantity
5mg USD 85 In stock
10mg USD 120 In stock
25mg USD 200 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SLx-2119, also known as KD-025, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). SLx-2119 (40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC.

In vivo, SLx-2119 (KD-025) (100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 452.51
Formula C26H24N6O2
CAS Number 911417-87-3
Purity >98%
Solubility DMSO: ≥ 25 mg/mL
Storage at -20°C
References

Selective ROCK2 Inhibition In Focal Cerebral Ischemia.
Lee JH, et al. Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14. PMID: 24466563.

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin.
Boerma M, et al. Blood Coagul Fibrinolysis. 2008 Oct;19(7):709-18. PMID: 18832915.

Related ROCK Products
BDP5290

BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

ZINC00881524

ZINC00881524 is a potent and selective ROCK inhibitor.

HA 1100 hydrochloride

HA 1100 hydrochloride is a cell-permeable, selective Rho-kinase inhibitor.

Ripasudil (K-115) dihydrate

Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

SR 3677

SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SLx-2119, KD-025 supplier, ROCK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.