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Y-27632

Cat. No. M20999
Y-27632 Structure
Size Price Availability Quantity
2mg USD 50  USD50 In stock
5mg USD 70  USD70 In stock
10mg USD 110  USD110 In stock
50mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

Chemical Information
Molecular Weight 247.34
Formula C14H21N3O
CAS Number 146986-50-7
Solubility (25°C) DMSO 49 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhiwei Xie, et al. Hum Exp Toxicol. Effects of Y-27632 on the osteogenic and adipogenic potential of human dental pulp stem cells in vitro

[2] Yutaka Koizumi, et al. Mol Brain. Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice

[3] Weijie Zhang, et al. Cornea. Y-27632 Promotes the Repair Effect of Umbilical Cord Blood-Derived Endothelial Progenitor Cells on Corneal Endothelial Wound Healing

[4] Li-Ya Dong, et al. Int J Mol Med. Y-27632, a Rho-kinase inhibitor, attenuates myocardial ischemia-reperfusion injury in rats

[5] Ting Wang, et al. J Cell Mol Med. Rho-kinase inhibitor Y-27632 facilitates the proliferation, migration and pluripotency of human periodontal ligament stem cells

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  Catalog
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