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Abmole Inhibitor Catalog 2017

HSP Heat shock proteins


Cat.No.  Name Information
M10496 HM03 HM03 is a potent and selective HSPA5 inhibitor with anticancer activity.
M10289 Cucurbitacin D Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
M9899 Arimoclomol maleate Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9846 JG-98 JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
M9304 KNK437 KNK437 is a novel inhibitor of acquisition of thermotolerance and heat shock protein.
M9299 HSF1A HSF1A is an activator of Heat shock transcription factor 1 (HSF1).
M9273 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.
M7575 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M5997 Teprenone Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.
M3884 Celastrol Celastrol is a potent antioxidant and anti-inflammatory agent and a novel HSP90 inhibitor.
M3776 CH5138303 CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
M3683 Retaspimycin Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
M3563 KW-2478 KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM.
M3561 Geldanamycin Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
M3528 SNX-2112 SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
M3197 MPC-3100 MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM.
M3117 VER-49009 VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.
M3116 VER 155008 VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90.
M2968 PU-H71 PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.
M2885 NMS-E973 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
M2777 IPI-504 hydrochloride IPI-504 (Retaspimycin) hydrochloride is a potent inhibitor of HSP90 with EC50 of 63 nM.
M2776 IPI-493 IPI-493 is a potent and orally bioavailable HSP90 inhibitor with Ki of 21 nM.
M2321 17-DMAG hydrochloride 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM.
M2320 17-AAG 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.
M2083 Elesclomol Elesclomol (formerly STA-4783) is a small-molecule investigational agent that selectively induces apoptosis in cancer cells by increasing oxidative stress.
M2070 XL888 XL888 is a novel small-molecule inhibitor of HSP90 with IC50 of 24 nM.
M2003 PF-04929113 PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM.
M1949 AT13387 AT13387 is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells.
M1908 NVP-BEP800 NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor of Hsp90β with an IC50 of 58 nM.
M1798 NVP-HSP990 NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
M1762 Luminespib (AUY922) Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively.
M1741 Ganetespib Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity.
M1725 CUDC-305 CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.
M1679 BIIB021 BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM.

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