Inhibitors
Cat.No. | Name | Information |
---|---|---|
M9899 | Arimoclomol maleate | Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
M9846 | JG-98 | JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. |
M9304 | KNK437 | KNK437 is a novel inhibitor of acquisition of thermotolerance and heat shock protein. |
M9299 | HSF1A | HSF1A is an activator of Heat shock transcription factor 1 (HSF1). |
M9273 | HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells. |
M7575 | Apoptozole | Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis. |
M5997 | Teprenone | Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins. |
M3884 | Celastrol | Celastrol is a potent antioxidant and anti-inflammatory agent and a novel HSP90 inhibitor. |
M3776 | CH5138303 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
M3683 | Retaspimycin | Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). |
M3563 | KW-2478 | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
M3561 | Geldanamycin | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. |
M3528 | SNX-2112 | SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. |
M3197 | MPC-3100 | MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM. |
M3117 | VER-49009 | VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β. |
M3116 | VER 155008 | VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90. |
M2968 | PU-H71 | PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. |
M2885 | NMS-E973 | NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. |
M2777 | IPI-504 | IPI-504 (Retaspimycin) is a potent inhibitor of HSP90 with EC50 of 63 nM. |
M2776 | IPI-493 | IPI-493 is a potent and orally bioavailable HSP90 inhibitor with Ki of 21 nM. |
M2321 | 17-DMAG hydrochloride | 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM. |
M2320 | 17-AAG | 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. |
M2083 | Elesclomol | Elesclomol (formerly STA-4783) is a small-molecule investigational agent that selectively induces apoptosis in cancer cells by increasing oxidative stress. |
M2070 | XL888 | XL888 is a novel small-molecule inhibitor of HSP90 with IC50 of 24 nM. |
M2003 | PF-04929113 | PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM. |
M1949 | AT13387 | AT13387 is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells. |
M1908 | NVP-BEP800 | NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor of Hsp90β with an IC50 of 58 nM. |
M1798 | NVP-HSP990 | NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. |
M1762 | AUY922 | AUY922 (NVP-AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively. |
M1741 | Ganetespib | Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity. |
M1725 | CUDC-305 | CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class. |
M1679 | BIIB021 | BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM. |
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