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Abmole Inhibitor Catalog 2017

HSP90 Heat shock protein 90

Inhibitors

Cat.No.  Name Information
M7575 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M5997 Teprenone Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.
M3884 Celastrol Celastrol is a potent antioxidant and anti-inflammatory agent and a novel HSP90 inhibitor.
M3776 CH5138303 CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
M3683 Retaspimycin Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
M3563 KW-2478 KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM.
M3561 Geldanamycin Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
M3528 SNX-2112 SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
M3197 MPC-3100 MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM.
M3117 VER-49009 VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.
M2968 PU-H71 PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.
M2885 NMS-E973 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
M2777 IPI-504 IPI-504 (Retaspimycin) is a potent inhibitor of HSP90 with EC50 of 63 nM.
M2776 IPI-493 IPI-493 is a potent and orally bioavailable HSP90 inhibitor with Ki of 21 nM.
M2321 17-DMAG hydrochloride 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM.
M2320 17-AAG 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.
M2083 Elesclomol Elesclomol (formerly STA-4783) is a small-molecule investigational agent that selectively induces apoptosis in cancer cells by increasing oxidative stress.
M2070 XL888 XL888 is a novel small-molecule inhibitor of HSP90 with IC50 of 24 nM.
M2003 PF-04929113 PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM.
M1949 AT13387 AT13387 is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells.
M1908 NVP-BEP800 NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor of Hsp90β with an IC50 of 58 nM.
M1798 NVP-HSP990 NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
M1762 AUY922 AUY922 (NVP-AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively.
M1741 Ganetespib Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity.
M1725 CUDC-305 CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.
M1679 BIIB021 BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM.


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