Catalog

HSP Heat shock proteins

Inhibitors

Cat.No.	Name	Information
M7575	Apoptozole	Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M5997	Teprenone	Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.
M3884	Celastrol	Celastrol is a potent antioxidant and anti-inflammatory agent and a novel HSP90 inhibitor.
M3776	CH5138303	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
M3683	Retaspimycin	Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
M3563	KW-2478	KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM.
M3561	Geldanamycin	Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
M3528	SNX-2112	SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with K_a of 30 nM and 30 nM, uniformly more potent than 17-AAG.
M3197	MPC-3100	MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM.
M3117	VER-49009	VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.
M3116	VER 155008	VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90.
M2968	PU-H71	PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.
M2885	NMS-E973	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
M2777	IPI-504	IPI-504 (Retaspimycin) is a potent inhibitor of HSP90 with EC50 of 63 nM.
M2776	IPI-493	IPI-493 is a potent and orally bioavailable HSP90 inhibitor with K_i of 21 nM.
M2321	17-DMAG hydrochloride	17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM.
M2320	17-AAG	17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.
M2083	Elesclomol	Elesclomol (formerly STA-4783) is a small-molecule investigational agent that selectively induces apoptosis in cancer cells by increasing oxidative stress.
M2070	XL888	XL888 is a novel small-molecule inhibitor of HSP90 with IC50 of 24 nM.
M2003	PF-04929113	PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM.
M1949	AT13387	AT13387 is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells.
M1908	NVP-BEP800	NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor of Hsp90β with an IC50 of 58 nM.
M1798	NVP-HSP990	NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
M1762	AUY922	AUY922 (NVP-AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively.
M1741	Ganetespib	Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity.
M1725	CUDC-305	CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.
M1679	BIIB021	BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM.

Signaling Pathways

Product Type

HSP Heat shock proteins

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