Free shipping on all orders over $ 500

Arimoclomol maleate

Cat. No. M9899
Arimoclomol maleate Structure
Synonym:

BRX-220

Size Price Availability Quantity
10mg USD 90  USD90 In stock
25mg USD 190  USD190 In stock
50mg USD 330  USD330 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). Arimoclomol stimulats a normal cellular protein repair pathway through the activation of molecular chaperones. In vivo, Arimoclomol (20 mg/kg; orally for 5 days) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis.

Product Citations
Chemical Information
Molecular Weight 429.85
Formula C18H24ClN3O7
CAS Number 289893-26-1
Solubility (25°C) Water 80 mg/mL
DMSO 120 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aubryanna Hettinghouse, et al. EBioMedicine. Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models

[2] Cathrine K Fog, et al. EBioMedicine. The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase

[3] Julie Phukan. IDrugs. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis

[4] Zoltan Rakonczay Jr, et al. Free Radic Biol Med. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats

Related HSP Products
Hsp70-derived octapeptide

Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs.

p5 Ligand for Dnak and DnaJ

p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase.

Tertomotide hydrochloride

Tertomotide hydrochloride is a peptide consisting of 16 amino acids containing sequences derived from human telomerase reverse transcriptase (TERT).Tertomotide penetrates cells and interacts with HSP70 and HSP90, as well as inhibiting amyloid beta and tau, and inhibiting aging-related signaling in the brain. pathways, which could be used in aging and Alzheimer's disease related studies.

BMS-986263

BMS-986263 is a small interfering RNA (siRNA) that targets Hsp47 and can be used in studies related to idiopathic pulmonary fibrosis (IPF).

AT-533

AT-533 is a potent Hsp90 and HSV inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: Arimoclomol maleate, BRX-220 supplier, HSP, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.