Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). Arimoclomol stimulats a normal cellular protein repair pathway through the activation of molecular chaperones. In vivo, Arimoclomol (20 mg/kg; orally for 5 days) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis.
IDrugs. 2010 Jul;13(7):482-96.
Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis
Arimoclomol maleate purchased from AbMole
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water 80 mg/mL
DMSO 120 mg/mL
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