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Arimoclomol maleate

Cat. No. M9899
Arimoclomol maleate Structure
Synonym:

BRX-220

Size Price Availability Quantity
10mg USD 100  USD100 In stock
25mg USD 200  USD200 In stock
50mg USD 330  USD330 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). Arimoclomol stimulats a normal cellular protein repair pathway through the activation of molecular chaperones. In vivo, Arimoclomol (20 mg/kg; orally for 5 days) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 429.85
Formula C18H24ClN3O7
CAS Number 289893-26-1
Purity >99%
Solubility Water 80 mg/mL
DMSO 120 mg/mL
Storage at -20°C
References

[1] Aubryanna Hettinghouse, et al. EBioMedicine. Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models

[2] Cathrine K Fog, et al. EBioMedicine. The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase

[3] Julie Phukan. IDrugs. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis

[4] Zoltan Rakonczay Jr, et al. Free Radic Biol Med. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Arimoclomol maleate, BRX-220 supplier, HSP, inhibitors

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