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HSF1A

Cat. No. M9299
HSF1A Structure
Size Price Availability Quantity
2mg USD 125 In stock
5mg USD 185 In stock
10mg USD 270 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

HSF1A is an activator of Heat shock transcription factor 1 (HSF1). HSF1A protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis. HSF1A enhances HSF1 activity, stabilizes HSF1 expression and minimizes Doxorubicin (DOX)-induced cardiac damage. HSF1A has been shown to stimulate human HSF1 nuclear translocation, elevate protein chaperone expression and ameliorate protein misfolding and cell death in a neurodegenerative disease model.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 409.52
Formula C21H19N3O2S2
CAS Number 1196723-93-9
Purity >98%
Solubility DMSO: ≥ 90 mg/mL
Storage at -20°C
References

Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death.
Huang CY, et al. Cell Death Dis. 2016 Nov 3;7(11):e2455. PMID: 27809308.

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.
Neef DW, et al. Cell Rep. 2014 Nov 6;9(3):955-66. PMID: 25437552.

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  Catalog
Abmole Inhibitor Catalog 2017




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