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VER-49009

Cat. No. M3117
VER-49009 Structure
Synonym:

CCT0129397

Size Price Availability
1mg USD 140  USD140 Out of stock
5mg USD 350  USD350 Out of stock
10mg USD 600  USD600 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.

Protocol
Cell Experiment
Cell lines Melanoma cells (SKMEL 2, SKMEL 5, SKMEL 28, WM266.4); Colon cancer cells (HCT116, BEneg, BE2, HT29, HT29oxaliR); Ovarian cancer cells (CH1, CH1doxR); Breast cancer cells (MB-231, MB-468, BT20, ZR751, MCF7, BT-474); nontumorigenic cells (HUVEC, MCF10a, PNT
Preparation method Using the sulforhodamine B assay to mearsure antiproliferative effects . Determining HUVEC sensitivity by an alkaline phosphatase method.
Concentrations ~10 μM
Incubation time 4 days
Animal Experiment
Animal models Mice bearing established OVCAR3 human ovarian xenografts
Formulation 10% DMSO, 5% Tween 20, 85% saline
Dosages ~4 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 387.82
Formula C19H18ClN3O4
CAS Number 940289-57-6
Purity >98%
Solubility DMSO 60 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VER-49009, CCT0129397 supplier, HSP, inhibitors

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