VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.
Cell Experiment | |
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Cell lines | Melanoma cells (SKMEL 2, SKMEL 5, SKMEL 28, WM266.4); Colon cancer cells (HCT116, BEneg, BE2, HT29, HT29oxaliR); Ovarian cancer cells (CH1, CH1doxR); Breast cancer cells (MB-231, MB-468, BT20, ZR751, MCF7, BT-474); nontumorigenic cells (HUVEC, MCF10a, PNT |
Preparation method | Using the sulforhodamine B assay to mearsure antiproliferative effects . Determining HUVEC sensitivity by an alkaline phosphatase method. |
Concentrations | ~10 μM |
Incubation time | 4 days |
Animal Experiment | |
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Animal models | Mice bearing established OVCAR3 human ovarian xenografts |
Formulation | 10% DMSO, 5% Tween 20, 85% saline |
Dosages | ~4 mg/kg |
Administration | i.p. |
Molecular Weight | 387.82 |
Formula | C19H18ClN3O4 |
CAS Number | 940289-57-6 |
Solubility (25°C) | DMSO 60 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Xavier Barril, et al. 4-Amino derivatives of the Hsp90 inhibitor CCT018159
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