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JG-98

Cat. No. M9846
JG-98 Structure
Synonym:

JG98

Size Price Availability Quantity
5mg USD 320  USD320 In stock
10mg USD 520  USD520 In stock
25mg USD 920  USD920 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 (10 μM) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells. In vivo, JG-98 (3 mg/kg; ip) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 534.54
Formula C24H21Cl2N3OS3
CAS Number 1456551-16-8
Purity >99%
Solubility DMSO 4 mg/mL
Storage at -20°C
References

[1] Julia A Yaglom, et al. Sci Rep. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations

[2] Xiaokai Li, et al. Mol Cancer Ther. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer

[3] Xiaokai Li, et al. ACS Med Chem Lett. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JG-98, JG98 supplier, HSP, inhibitors

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