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HM03

Cat. No. M10496
HM03 Structure
Synonym:

HM-03; NSC130813

Size Price Availability Quantity
10mg USD 100  USD100 In stock
50mg USD 350  USD350 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

HM03 is a potent and selective HSPA5 inhibitor with anticancer activity. HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 462.97
Formula C26H27ClN4O2
CAS Number 500565-15-1
Purity >98%
Solubility DMSO 100 mg/mL
Storage at -20°C
References

[1] Meilan Huang, et al. Bioorg Med Chem Lett. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: HM03, HM-03; NSC130813 supplier, HSP, inhibitors

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