Free shipping on all orders over $ 500
HM03 is a potent and selective HSPA5 inhibitor with anticancer activity. HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 462.97 |
| Formula | C26H27ClN4O2 |
| CAS Number | 500565-15-1 |
| Purity | >98% |
| Solubility | DMSO 100 mg/mL |
| Storage | at -20°C |
| Related HSP Products |
|---|
| NPX800
NPX800 is an oral HSF1 inhibitor of FIC. NPX800 has the potential to be used in cancer research. |
| Shepherdin (79-87)
Shepherdin (79-87) is a 79 to 87 amino acid fragment of Shepherdin. Shepherdin is a peptide-mimetic antagonist of Hsp90-Survivin complex. Has antitumor activity. |
| Calenduloside E
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90). |
| Cucurbitacin D
Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. |
| Arimoclomol maleate
Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
