|M8958||Ivosidenib||Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.|
|M6034||Trilostane||Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.|
|M5663||Fomepizole||Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.|
|M4876||Vidofludimus||Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH.|
|M3721||ML323||ML323 is a highly potent and selective USP1-UAF1 inhibitor with IC50 of 76 nM.|
|M3518||MK-8245||MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.|
|M2563||NSC 14613||NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.|
|M2371||AGI-6780||AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.|
|M2297||CPI-613||CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase.|
|M2139||Mycophenolate mofetil||Mycophenolate mofetil is an inhibitor of inosine monophosphate dehydrogenase (IMPDH).|
|M2067||AGI-5198||AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 μM and 0.16 μM, respectively.|
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