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Fomepizole

Cat. No. M5663
Fomepizole Structure
Synonym:

4-methylpyrazole, Antizol, Antizol-Vet

Size Price Availability Quantity
500mg USD 56 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 82.1
Formula C4H6N2
CAS Number 7554-65-6
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Fomepizole versus ethanol in the treatment of acute methanol poisoning: Comparison of clinical effectiveness in a mass poisoning outbreak.
Zakharov S, et al. Clin Toxicol (Phila). 2015;53(8):797-806. PMID: 26109326.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Fomepizole, 4-methylpyrazole, Antizol, Antizol-Vet supplier, Dehydrogenase, inhibitors

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