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Trilostane

Cat. No. M6034
Trilostane Structure
Synonym:

WIN 24540

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 200 In stock
100mg USD 300 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 329.43
Formula C20H27NO3
CAS Number 13647-35-3
Purity >99%
Solubility 65 mg/mL in DMSO
Storage at -20°C
References

Cortisol Concentrations in Well-Regulated Dogs with Hyperadrenocorticism Treated with Trilostane.
Midence JN, et al. J Vet Intern Med. 2015 Nov-Dec;29(6):1529-33. PMID: 26374943.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Trilostane, WIN 24540 supplier, Dehydrogenase, inhibitors

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