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Cat. No. M4930
SW033291 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 87 In stock
10mg USD 145 In stock
50mg USD 450 In stock
100mg USD 670 In stock
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Quality Control
Biological Activity

SW033291 inhibition of 15-PGDH was noncompetitive versus PGE2 over concentrations up to 40 μM PGE2. SW033291 also demonstrated selective high-affinity interaction with 15-PGDH in thermal denaturation assays. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with 50% of maximal stimulation (EC50) at ~75 nM.

Customer Product Validations & Biological Datas
Source Sci Rep (2018). Figure 5. SW033291
Method Treatment of diseased tendon stromal cells with inhibitors of 15-PGDH
Cell Lines tendon stromal cells 
Concentrations 25 μM
Incubation Time 2 h
Results In incubations of IL-1β stimulated diseased tendon stromal cells with either indomethacin or SW033291, we found significantly lower concentrations of 15-oxo-LXA4 and 14-oxo-MaR1 levels, and a corresponding increase in the levels of 15-epi-LXA4 and MaR1
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 412.59
Formula C21H20N2OS3
CAS Number 459147-39-8
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C

TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang Y, Science. 2015 Jun 12;348(6240). PMID: 26068857.

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Keywords: SW033291 supplier, Dehydrogenase, inhibitors

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