| Cat.No. | Name | Information |
|---|---|---|
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M41861 | VU0364572 TFA | VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. |
| M41860 | Arecaidine but-2-ynyl ester tosylate | Arecaidine but-2-ynyl ester tosylate (ABET) is a selective mAChR M2 agonist that dose-dependently decreases mean arterial pressure and heart rate in rats. |
| M41000 | (R)-Oxybutynin | (R)-Oxybutynin is a racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. It has antitussive and anticholinergic activity, competitively antagonizes carbachol-induced contractions, and can be used in studies related to obstructive sleep apnea (OSA). |
| M40911 | Octahydroaminoacridine succinate | Octahydroaminoacridine succinate is a Tacrine analog and a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It may be used in studies related to Alzheimer's disease (AD). |
| M39202 | Cyclopenin | Cyclopenin ((±)-Isocyclopenine) is a racemate. |
| M39201 | Lycodoline | Lycodoline is a alkaloid with butyrylcholinesterase (BChE) (IC50 of 667 μM) inhibition activities. |
| M39200 | Vomifoliol | Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate antileishmanial activity. |
| M39199 | Isonaringin | Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE. |
| M39198 | Huperzine C | Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC50 of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease. |
| M39197 | Leptomerine | Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity. |
| M39196 | Isorosmanol | Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis. |
| M39195 | Broussonin A | Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation. |
| M39194 | (-)-Corynoxidine | (-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees. |
| M39193 | Dehydrodicentrine | Dehydrodicentrine is an aporphine alkaloid can be isolated from the root of S. epigaea and has inhibitory effect on acetylcholinesterase (AChE) with an IC50 value of 2.98 μM. |
| M39192 | Chikusetsusaponin Ib | Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor. |
| M39034 | Ferulamide | Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L. with anticholinesterase activities. |
| M39033 | (±)-Coniine hydrochloride | (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg. |
| M31050 | Rivanicline hemioxalate | Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM). |
| M31049 | (S)-UFR2709 hydrochloride | (S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction. |
| M30956 | Sulfoxaflor | Sulfoxaflor is a sulfoximine insecticide and is an agonist of nAChR1 and nAChR2 subtypes. Sulfoxaflor is used for the control of sap-feeding insects such as Myzus persicae, Aphis gossypii, Bemissia tabaci and Nilaparvata lugens. |
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