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Carbachol chloride

Cat. No. M2489
Carbachol chloride Structure
Synonym:

Carbamylcholine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 30  USD30 In stock
50mg USD 50  USD50 In stock
100mg USD 62  USD62 In stock
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Quality Control & Documentation
Biological Activity

Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.

Product Citations
Customer Product Validations & Biological Datas
Source Customer experimental result (2018).
Method Western blot
Cell Lines
Concentrations 10 uM
Incubation Time 0-120 mins
Results Western blot results showed that Carbachol has a good inhibitory effect on PKD1.
Chemical Information
Molecular Weight 182.65
Formula C6H15N2O2.Cl
CAS Number 51-83-2
Solubility (25°C) Water 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Younjoo Kim, et al. Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea

[2] S-H Tang, et al. Propofol inhibits carbachol-induced chloride secretion by directly targeting the basolateral K + channel in rat ileum epithelium

[3] N Bekkali, et al. The role of rectal chloride secretion in childhood constipation

[4] D H Jenkinson, et al. Influence of chloride ions on changes in membrane potential during prolonged application of carbachol to frog skeletal muscle

[5] K Dharmsathaphorn, et al. Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line

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Keywords: Carbachol chloride, Carbamylcholine supplier, AChR/AChE, inhibitors, activators


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