Oxybutynin is a synthetic tertiary amine compound that competitively antagonizes muscarinic acetylcholine receptors (mAChRs) such as M1, M2, and M3, as well as inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 ± 0.38 μmol/L and a Hill coefficient (n) of 2.25 ± 0.12.
Front Bioeng Biotechnol. 2022 Jun 27;10:906835.
Injectable, Adhesive, and Self-Healing Composite Hydrogels Loaded With Oxybutynin Hydrochloride for the Treatment of Overactive Bladder in Rats
Oxybutynin purchased from AbMole
Molecular Weight | 357.49 |
Formula | C22H31NO3 |
CAS Number | 5633-20-5 |
Form | Solid |
Solubility (25°C) | DMSO 70 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] James Anthony Tony Harley. Oxybutynin for methadone-induced sweating in pregnancy
[2] Claudine M Baldwin, et al. Transdermal oxybutynin
[3] Daniel Duh, et al. Oxybutynin-Kentera
[4] Ananias Diokno, et al. Oxybutynin in detrusor overactivity
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