Catalog

AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

Inhibitors

Cat.No.	Name	Information
M10294	Scopolamine hydrobromide trihydrate	Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM.
M10154	Choline Glycerophosphate	Choline Glycerophosphate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue.
M9768	MK-7622	MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator.
M9590	Acotiamide dihydrochloride	Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE).
M9562	Huperzine A	Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb.
M9519	Nelonicline	Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist.
M8888	Donepezil	Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
M7853	Ipratropium bromide monohydrate	Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
M7585	Atropine	Atropine (Tropine tropate) is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.
M7227	EVP-6124 hydrochloride	EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
M6273	Varenicline tartrate	Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
M6268	Varenicline	Varenicline (CP 526555) is a selective α4β2 nicotinic receptor partial agonist, it stimulates nicotine receptors more weakly than nicotine itself does.
M6127	TD-4208	TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.
M6040	Tropicamide	Tropicamide (Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
M6016	Tiotropium Bromide	Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
M5810	Neostigmine methyl sulfate	Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.
M5672	Galanthamine HBr	Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
M5604	Edrophonium chloride	Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
M5584	Diphenidol HCl	Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.
M5433	Atropine Sulfate Monohydrate	Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
M5389	Adiphenine HCl	Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
M5194	VU0357017 hydrochloride	VU0357017 hydrochloride is a highly selective M1 agonist that appear to act at an allosteric site to activate the receptor.
M4457	Jatrorrhizine chloride	Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE.
M4402	Epiberberine	Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).
M4188	Tenuifolin	Tenuifolin
M3606	Neostigmine Bromide	Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
M3601	Donepezil hydrochloride	Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
M3590	Butylscopolamine Bromide	Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.
M3589	Methscopolamine bromide	Methscopolamine is a muscarinic acetylcholine receptor blocker.
M3534	Pancuronium dibromide	Pancuronium dibromide is a competitive acetylcholine antagonist with an IC50 of 5.5 nM.
M3501	Ipratropium Bromide	Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.
M3453	Scopolamine hydrobromide	Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.
M3331	Trospium chloride	Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.
M3309	Bethanechol chloride	Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
M3225	Atropine sulfate	Atropine sulfate is a competitive muscarinic acetylcholine receptor antagonist.
M3190	PNU-282987	PNU-282987 is a highly selective α7 nAChR agonist with K_i of 27 nM.
M3046	Tacrine hydrochloride	Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist.
M3025	Solifenacin succinate	Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
M2944	Pilocarpine hydrochloride	Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. *The compound is unstable in solutions, freshly prepared is recommended
M2909	Oxybutynin chloride	Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
M2762	Hyoscyamine	Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
M2613	Darifenacin hydrobromide	Darifenacin is a selective M3 muscarinic receptor antagonist with pK_i of 8.9.
M2489	Carbachol chloride	Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M2441	Benzethonium Chloride	Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
M2368	Aclidinium Bromide	Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with K_i of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
M2268	Rocuronium bromide	Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
M2243	Aniracetam	Aniracetam is a nootropic compound that has been shown to selectively enhance quisqualate receptor-mediated responses in Xenopus oocytes injected with brain mRNA and in hippocampal pyramidal cells.

Signaling Pathways

Product Type

AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

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