Catalog

AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

Inhibitors

Cat.No.	Name	Information
M8888	Donepezil	Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
M7585	Atropine	Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.
M6273	Varenicline tartrate	Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
M6127	TD-4208	TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.
M6040	Tropicamide	Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
M6016	Tiotropium Bromide	Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
M5810	Neostigmine methyl sulfate	Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.
M5672	Galanthamine HBr	Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
M5604	Edrophonium chloride	Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
M5433	Atropine Sulfate Monohydrate	Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
M5389	Adiphenine	Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
M4188	Tenuifolin	Tenuifolin
M3601	Donepezil hydrochloride	Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
M3590	Butylscopolamine Bromide	Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.
M3589	Methscopolamine bromide	Methscopolamine is a muscarinic acetylcholine receptor blocker.
M3534	Pancuronium dibromide	Pancuronium dibromide is a competitive acetylcholine antagonist with an IC50 of 5.5 nM.
M3453	Scopolamine hydrobromide	Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.
M3309	Bethanechol chloride	Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
M3190	PNU-282987	PNU-282987 is a highly selective α7 nAChR agonist with K_i of 27 nM.
M3025	Solifenacin succinate	Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
M2944	Pilocarpine hydrochloride	Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
M2762	Hyoscyamine	Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
M2613	Darifenacin hydrobromide	Darifenacin is a selective M3 muscarinic receptor antagonist with pK_i of 8.9.
M2489	Carbachol	Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M2368	Aclidinium Bromide	Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with K_i of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
M2268	Rocuronium bromide	Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.

Signaling Pathways

Product Type

AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

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