Inhibitors
Cat.No. | Name | Information |
---|---|---|
M9768 | MK-7622 | MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator. |
M9590 | Acotiamide dihydrochloride | Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). |
M9562 | Huperzine A | Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb. |
M9519 | Nelonicline | Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist. |
M8888 | Donepezil | Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively. |
M7585 | Atropine | Atropine (Tropine tropate) is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors. |
M7227 | EVP-6124 hydrochloride | EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
M6273 | Varenicline tartrate | Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction. |
M6127 | TD-4208 | TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity. |
M6040 | Tropicamide | Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM. |
M6016 | Tiotropium Bromide | Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. |
M5810 | Neostigmine methyl sulfate | Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier. |
M5672 | Galanthamine HBr | Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. |
M5604 | Edrophonium chloride | Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction. |
M5433 | Atropine Sulfate Monohydrate | Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery. |
M5389 | Adiphenine | Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug. |
M5194 | VU0357017 hydrochloride | VU0357017 hydrochloride is a highly selective M1 agonist that appear to act at an allosteric site to activate the receptor. |
M4188 | Tenuifolin | Tenuifolin |
M3606 | Neostigmine Bromide | Neostigmine Bromide is a reversible acetylcholinesterase inhibitor. |
M3601 | Donepezil hydrochloride | Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
M3590 | Butylscopolamine Bromide | Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic. |
M3589 | Methscopolamine bromide | Methscopolamine is a muscarinic acetylcholine receptor blocker. |
M3534 | Pancuronium dibromide | Pancuronium dibromide is a competitive acetylcholine antagonist with an IC50 of 5.5 nM. |
M3453 | Scopolamine hydrobromide | Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM. |
M3331 | Trospium chloride | Trospium chloride is a competitive muscarinic cholinergic receptor antagonist. |
M3309 | Bethanechol chloride | Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors. |
M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
M3025 | Solifenacin succinate | Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class. |
M2944 | Pilocarpine hydrochloride | Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. |
M2762 | Hyoscyamine | Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM. |
M2613 | Darifenacin hydrobromide | Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9. |
M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
M2368 | Aclidinium Bromide | Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively. |
M2268 | Rocuronium bromide | Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia. |
M2243 | Aniracetam | Aniracetam is a nootropic compound that has been shown to selectively enhance quisqualate receptor-mediated responses in Xenopus oocytes injected with brain mRNA and in hippocampal pyramidal cells. |
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