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Abmole Inhibitor Catalog 2017

AChR/AChE Acetylcholine Receptors/Acetylcholinesterase


Cat.No.  Name Information
M10294 Scopolamine hydrobromide trihydrate Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM.
M10154 Choline Glycerophosphate Choline Glycerophosphate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue.
M9768 MK-7622 MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator.
M9590 Acotiamide dihydrochloride Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE).
M9562 Huperzine A Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb.
M9519 Nelonicline Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist.
M8888 Donepezil Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
M7853 Ipratropium bromide monohydrate Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
M7585 Atropine Atropine (Tropine tropate) is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.
M7227 EVP-6124 hydrochloride EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
M6273 Varenicline tartrate Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
M6268 Varenicline Varenicline (CP 526555) is a selective α4β2 nicotinic receptor partial agonist, it stimulates nicotine receptors more weakly than nicotine itself does.
M6127 TD-4208 TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.
M6040 Tropicamide Tropicamide (Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
M6016 Tiotropium Bromide Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
M5810 Neostigmine methyl sulfate Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.
M5672 Galanthamine HBr Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
M5604 Edrophonium chloride Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
M5584 Diphenidol HCl Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.
M5433 Atropine Sulfate Monohydrate Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
M5389 Adiphenine HCl Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
M5194 VU0357017 hydrochloride VU0357017 hydrochloride is a highly selective M1 agonist that appear to act at an allosteric site to activate the receptor.
M4457 Jatrorrhizine chloride Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE.
M4402 Epiberberine Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).
M4188 Tenuifolin Tenuifolin
M3606 Neostigmine Bromide Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
M3601 Donepezil hydrochloride Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
M3590 Butylscopolamine Bromide Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.
M3589 Methscopolamine bromide Methscopolamine is a muscarinic acetylcholine receptor blocker.
M3534 Pancuronium dibromide Pancuronium dibromide is a competitive acetylcholine antagonist with an IC50 of 5.5 nM.
M3501 Ipratropium Bromide Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.
M3453 Scopolamine hydrobromide Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.
M3331 Trospium chloride Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.
M3309 Bethanechol chloride Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
M3225 Atropine sulfate Atropine sulfate is a competitive muscarinic acetylcholine receptor antagonist.
M3190 PNU-282987 PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM.
M3046 Tacrine hydrochloride Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist.
M3025 Solifenacin succinate Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
M2944 Pilocarpine hydrochloride Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. *The compound is unstable in solutions, freshly prepared is recommended
M2909 Oxybutynin chloride Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
M2762 Hyoscyamine Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
M2613 Darifenacin hydrobromide Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
M2489 Carbachol chloride Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M2441 Benzethonium Chloride Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
M2368 Aclidinium Bromide Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
M2268 Rocuronium bromide Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
M2243 Aniracetam Aniracetam is a nootropic compound that has been shown to selectively enhance quisqualate receptor-mediated responses in Xenopus oocytes injected with brain mRNA and in hippocampal pyramidal cells.

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