Catalog

AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

Inhibitors

Cat.No.	Name	Information
M9768	MK-7622	MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator.
M9590	Acotiamide dihydrochloride	Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE).
M9562	Huperzine A	Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb.
M9519	Nelonicline	Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist.
M8888	Donepezil	Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
M7585	Atropine	Atropine (Tropine tropate) is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.
M7227	EVP-6124 hydrochloride	EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
M6273	Varenicline tartrate	Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
M6127	TD-4208	TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.
M6040	Tropicamide	Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
M6016	Tiotropium Bromide	Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
M5810	Neostigmine methyl sulfate	Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.
M5672	Galanthamine HBr	Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
M5604	Edrophonium chloride	Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
M5433	Atropine Sulfate Monohydrate	Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
M5389	Adiphenine	Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
M5194	VU0357017 hydrochloride	VU0357017 hydrochloride is a highly selective M1 agonist that appear to act at an allosteric site to activate the receptor.
M4188	Tenuifolin	Tenuifolin
M3606	Neostigmine Bromide	Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
M3601	Donepezil hydrochloride	Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
M3590	Butylscopolamine Bromide	Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.
M3589	Methscopolamine bromide	Methscopolamine is a muscarinic acetylcholine receptor blocker.
M3534	Pancuronium dibromide	Pancuronium dibromide is a competitive acetylcholine antagonist with an IC50 of 5.5 nM.
M3453	Scopolamine hydrobromide	Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM.
M3331	Trospium chloride	Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.
M3309	Bethanechol chloride	Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
M3190	PNU-282987	PNU-282987 is a highly selective α7 nAChR agonist with K_i of 27 nM.
M3025	Solifenacin succinate	Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
M2944	Pilocarpine hydrochloride	Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
M2762	Hyoscyamine	Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
M2613	Darifenacin hydrobromide	Darifenacin is a selective M3 muscarinic receptor antagonist with pK_i of 8.9.
M2489	Carbachol chloride	Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M2368	Aclidinium Bromide	Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with K_i of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
M2268	Rocuronium bromide	Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
M2243	Aniracetam	Aniracetam is a nootropic compound that has been shown to selectively enhance quisqualate receptor-mediated responses in Xenopus oocytes injected with brain mRNA and in hippocampal pyramidal cells.

Signaling Pathways

Product Type

AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

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