| Cat.No. | Name | Information |
|---|---|---|
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M14548 | Galanthamine | Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. |
| M14547 | Epiberberine chloride | Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. |
| M14008 | Umeclidinium bromide | Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM. |
| M11552 | DREADD agonist 21 | DREADD Agonist 21 is an effective agonist for human muscarinic acetylcholine M3 receptor (hM3Dq) (EC50=1.7 nM). |
| M11551 | Deschloroclozapine | Deschloroclozapine is an effective, high affinity, selective, metabolically stable agonist based on muscarinic DREADDs. The Ki binding values of Deschloroclozapine to DREADD receptor subtypes hM3Dq and hM4Di were 6.3 and 4.2 nM, respectively. |
| M11534 | Altenuene | Altenuene belongs to plant extraction compounds, hydrophilic plant extracts can choose water, methanol, ethanol as solvents, lipophilic plant extracts please choose petroleum ether, benzene and other organic solvents. |
| M11348 | Garcinol | Garcinol is a kind of polyisoprene diphenylketone extracted from Garcinia japonicum. It has anticholinesterase properties for AChE and butyrylcholinesterase (BChE) with IC50 of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibited histone acetyltransferases (HATs, IC50=7 μM) and P300 /CPB related factors (PCAF, IC50=5 μM). Garcinol has anti-inflammatory and anticancer activities. |
| M10928 | Rivastigmine | Rivastigmine (S-Rivastigmine) is an orally active, potent cholinesterase (ChE) inhibitor that inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE),IC50 0.037 μM and 4.15 μM, respectively. Rivastigmine can pass through the blood-brain barrier (BBB). Rivastigmine is an parasympathetic or cholinergic agent used to study dementia caused by mild to moderate Alzheimer's and Parkinson's disease. |
| M10906 | Xanomeline | Xanomeline increases neuronal excitability as a potent selective muscarinic 1 and type 4 (M1/M4) receptor agonist. Xanomeline can be used in the study of neurological disorders such as schizophrenia. |
| M10873 | Pirmenol hydrochloride | Pirmenol hydrochloride inhibits IK.ACh (IC50=0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease. |
| M10830 | Corynantheine | Corynantheine (Hirsuteine) is an indole alkaloid extracted from Uncaria rhynchophylla. Corynantheine (Hirsuteine) antagonizes nicotine-mediated dopamine release non-competitively by blocking ion permeation through nicotinic receptor channel complexes. |
| M10659 | Picfeltarraenin IV | Picfeltarraenin IV is an acetylcholinesterase (AChE) inhibitor, which is obtained from Picriafel-terrae Lour (P.fel-terrae). |
| M10655 | Picfeltarraegenin X | Picfeltarraenin X is an AChE inhibitor, which is a triterpenoid isolated from Picria fel-terrae Lour. |
| M10623 | Dehydronuciferine | Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL |
| M10619 | Rhodiosin | Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. |
| M10616 | Picfeltarraenin IA | Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. |
| M10294 | Scopolamine hydrobromide trihydrate | Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. |
| M10154 | Choline Glycerophosphate | Choline Glycerophosphate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. |
| M9768 | MK-7622 | MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator. |
| M9607 | VU0119498 | VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM). |
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