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Sinapine

Cat. No. M14550
Sinapine Structure
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Biological Activity

Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

Chemical Information
Molecular Weight 310.36
CAS Number 18696-26-9
Solubility (25°C) DMSO 150 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Youdong Li, et al. Sinapine-enriched rapeseed oils reduced fatty liver formation in high-fat diet-fed C57BL/6J mice

[2] Yang Liu, et al. Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome

[3] Z T Yang, et al. [Extraction and Separation of Sinapine from Rapeseed Cake and the Mode of Action of Melanin Production Inhibition]

[4] Doria Boulghobra, et al. Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes

[5] Youdong Li, et al. Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota

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  Catalog
Abmole Inhibitor Catalog




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