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  Catalog
Abmole Inhibitor Catalog 2017

ROR Retinoic Acid-related Orphan Receptor

Inhibitors

Cat.No.  Name Information
M9265 Vimirogant Vimirogant (also known as AGN-242428 and VTP-43742) is a potent, selective and orally active RORγt inhibitor.
M9221 GSK805 GSK805 is a potent, orally bioavailable RORγγ Inhibitor, with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.
M9220 SR2211 SR2211 is a synthetic RORγ-selective modulator, functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
M7321 SR 1001 SR 1001 is a RORα/γ inverse agonist with Ki values of 172 and 111 nM, respectively.
M5676 SR1078 SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability.
M5675 SR3335 SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays.


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