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SR2211

Cat. No. M9220
SR2211 Structure
Size Price Availability
5mg USD 207  USD230 1-2 Weeks
10mg USD 360  USD400 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SR2211 is a synthetic RORγ-selective modulator that potently inhibits production of IL-17 in cells. In vitro, treatment of EL4 with SR2211 represses the IL-17 gene expression. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211. Treatment of EL-4 cells with SR2211 results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 527.48
Formula C26H24F7N3O
CAS Number 1359164-11-6
Purity >98%
Solubility DMSO
Storage at -20°C
References

Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation.
Song Y, et al. Eur J Med Chem. 2016 Jun 30;116:13-26. PMID: 27043267.

Identification of SR2211: a potent synthetic RORγ-selective modulator.
Kumar N, et al. ACS Chem Biol. 2012 Apr 20;7(4):672-7. PMID: 22292739.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SR2211 supplier, ROR, inhibitors

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