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SR 1001 is a retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). SR1001 demonstrates no activity at RORβ or LXR. SR1001 suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.
Basic Clin Pharmacol Toxicol. 2021 Nov;129(5):357-368.
RORγt inhibitor SR1001 alleviates acute pancreatitis by suppressing pancreatic IL‐17‐producing Th17 and γδ‐T cells in mice with ceruletide‐induced pancreatitis
SR 1001 purchased from AbMole
| Molecular Weight | 477.4 |
| Formula | C15H13F6N3O4S2 |
| CAS Number | 1335106-03-0 |
| Solubility (25°C) | DMSO 41 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ROR Products |
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| SAR-441169
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| GRC-39815
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| RORγ antagonist 1
RORγ antagonist 1, a potent betulinic acid derivative, is an antagonist of RORγ (KD=0.18 μM). |
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