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SR 1001

Cat. No. M7321
SR 1001 Structure
Size Price Availability Quantity
5mg USD 88.2  USD98 In stock
10mg USD 149.4  USD166 In stock
50mg USD 612  USD680 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SR 1001 is a retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). SR1001 demonstrates no activity at RORβ or LXR. SR1001 suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 477.4
Formula C15H13F6N3O4S2
CAS Number 1335106-03-0
Purity >98%
Solubility DMSO 41 mg/mL
Storage at -20°C
References

Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Crumbley C, et al. PLoS One. 2012;7(4):e33804. PMID: 22485150.

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt LA, et al. Nature. 2011 Apr 28;472(7344):491-4. PMID: 21499262.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SR 1001 supplier, ROR, inhibitors

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