Free shipping on all orders over $ 500

Vimirogant

Cat. No. M9265
Vimirogant Structure
Synonym:

AGN-242428; VTP-43742; RORγ-IN-1

Size Price Availability
1mg USD 800 Custom Synthesis
5mg USD 2700 Custom Synthesis
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vimirogant is a RORγ inhibitor, which has a Ki value of <100 nM. Vimirogant is used for the research of treating autoimmune disorders, including multiple sclerosis and psoriasis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 552.65
Formula C27H35F3N4O3S
CAS Number 1802706-04-2
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses.
Pandya VB, et al. J Med Chem. 2018 Dec 27;61(24):10976-10995. PMID: 30010338.

RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345.
Gege C, et al. Expert Opin Ther Pat. 2017 Jan;27(1):1-8. PMID: 27852111.

Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742.
Gege C. Expert Opin Ther Pat. 2016 Jun;26(6):737-44. PMID: 26895086.

Related ROR Products
GSK805

GSK805 is a potent, orally bioavailable RORγγ Inhibitor, with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.

SR2211

SR2211 is a synthetic RORγ-selective modulator, functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

SR 1001

SR 1001 is a RORα/γ inverse agonist with Ki values of 172 and 111 nM, respectively.

SR1078

SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability.

SR3335

SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vimirogant, AGN-242428; VTP-43742; RORγ-IN-1 supplier, ROR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.