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Neoruscogenin

Cat. No. M10106
Neoruscogenin Structure
Size Price Availability Quantity
5mg USD 171  USD190 In stock
10mg USD 283.5  USD315 In stock
25mg USD 513  USD570 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 428.61
Formula C27H40O4
CAS Number 17676-33-4
Purity >99%
Solubility DMSO 30 mg/mL
Ethanol 30 mg/mL
Storage at -20°C
References

The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1)
Stephane Helleboid, et al. J Biomol Screen. 2014 Mar;19(3):399-406. PMID: 23896689.

Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells
M Barbic, et al. Phytochemistry. 2013 Jun;90:106-13. PMID: 23499166.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Neoruscogenin supplier, ROR, inhibitors

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