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GSK2981278

Cat. No. M8943
GSK2981278 Structure
Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 255 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

GSK2981278 is a strong RORγ-selective inverse agonist that inhibits activation of the il17 promoter. GSK2981278 robustly inhibits RORγ-mediated cytokine production at both the mRNA and protein level. GSK2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK2981278 will significantly limit Th17-type cytokine expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 461.61
Formula C25H35NO5S
CAS Number 1474110-21-8
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin.
Smith SH, et al. PLoS One. 2016 Feb 12;11(2):e0147979. PMID: 26870941.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GSK2981278 supplier, inhibitors

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