mTOR inhibitor-12 - Search Results

About 4 results found for searched term "mTOR inhibitor-12" (0.123 seconds)

Cat.No.	Name	Target
M43384	mTOR inhibitor-12	mTOR
	mTOR inhibitor-12 is a selective brain penetrant mTOR inhibitor without genotoxicity risk.
M10471	MTI-31 (LXI-15029)	mTOR
	LXI-15029; MTI31
	MTI-31 (LXI-15029) is a novel low-toxicity mTORC1/mTORC2 inhibitor, demonstrated a potent mTOR binding affinity with >5000 fold selectivity over the related PI3K family isoforms. MTI-31 inhibited mTORC1- and mTORC2 function at ≤120 nM in cellular assays.
M21167	RMC-5552	mTOR
	The selective mTORC1 complex inhibitor RMC-4529 is a bidentate inhibitor that has a rapamycin-derived, FKBP12-induced heterologous mTOR inhibitor covalently linked to an active-site (orthologous) inhibitor.
M28992	RapaLink-1	mTOR
	RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity.