About 1 result found for searched term "ZX-29 " (0.116 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29459 | ZX-29 | ALK |
| ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. | ||
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