About 16 results found for searched term "YS-49" (0.321 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3713 | YS-49 | PI3K |
| YS 49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity. | ||
| M6166 | Bevacizumab | VEGFR/PDGFR |
| bevacizumab；Avastin | ||
| Bevacizumab (anti-VEGF, Avastin) is a humanized anti-VEGF monoclonal antibody that is an inhibitor of VEGF. It binds to, and neutralizes, all human-derived VEGF-A isoforms (and biologically active protein hydrolysis fragments).MW:149 KD. | ||
| M6297 | Upadacitinib | JAK |
| ABT-494 | ||
| Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research. | ||
| M11533 | Recombinant Human DKK-1 (Mammalian, N-8His) | Recombinant Proteins |
| Dickkopf-related protein 1;Dickkopf-1;Dkk-1 | ||
| Recombinant human DKK-1 protein (N-8HIS) is produced by Mammalian expression system, and the target gene encoding Thr32-HIS266 is expressed at the N-terminal with 8His marker. Accession # : O94907. | ||
| M25541 | SKF-82958 hydrobromide | Dopamine Receptor |
| (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide | ||
| SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM). | ||
| M13760 | 5(6)-CFDA | Cell Staining |
| 5-(6)-Carboxyfluorescein diacetate; CFDA | ||
| 5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) is a cell-permeant, amine-reactive green fluorescent probe used to stain cells for analysis in applications. (λex: 492 nm; λem: 517 nm). | ||
| M13770 | BCECF | Fluorescent Dye |
| 2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein | ||
| BCECF is a pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0–8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm. | ||
| M14880 | BMX-IN-1 | BTK |
| BMX kinase inhibitor | ||
| BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. | ||
| M19977 | Recombinant Human PRCP (Mammalian, C-6His) | Recombinant Proteins |
| Lysosomal Pro-X Carboxypeptidase; Angiotensinase C | ||
| Recombinant human lysosomal Pro-X carboxypeptidase was produced by the mammalian expression system with the target gene encoding Leu22-HIS496 expressing the 6His tag at the C-terminus. Protein number: P42785. | ||
| M21140 | Icenticaftor | CFTR |
| QBW251 | ||
| Icenticaftor (QBW251) is an oral enhancer of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with an EC50 of 79 nM for F508del and 497 nM for G551D CFTR. Icenticaftor can be used in chronic obstructive pulmonary disease (COPD) and cystic fibrosis studies. | ||
| M21526 | Recombinant Human S100A11 (E.coli ) | Recombinant Proteins |
| Protein S100-A11; Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70 | ||
| The recombinant human protein S100-A11 was produced by the expression system of Escoli and the target gene Met1-Thr105 was expressed. Protein number: P31949. | ||
| M21784 | AZ1495 | IRAK |
| AZ1495 is a weak base and orally active, potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with a Kd value of 0.0007 μM.AZ1495 has good physicochemical and kinase selectivity for IRAK4 and IRAK1, with IC50 values of 0.005 μM and 0.023 μM, respectively.AZ1495 is used in studies of diffuse large B-cell lymphoma (DLBCL). | ||
| M27768 | GRL-0496 | Anti-infection |
| GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM. | ||
| M27934 | AS1949490 | Phosphatase |
| AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes. | ||
| M30447 | RU 24969 hemisuccinate | 5-HT Receptor |
| RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion. | ||
| M45399 | CUR5g | Autophagy |
| CUR5g is a potent autophagy inhibitor that selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g also prevents STX17 from being recruited to autophagosomes through a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. In addition, CUR5g enhances the in vitro and in vivo anticancer effects of cisplatin in A549 cells. | ||
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